Statistical Optimization Amalgamated Approach on Formulation Development of Nano Lipid Carrier Loaded Hydrophilic Gel of Fluticasone Propionate

Abstract: Introduction: Formulation of a nano lipid carrier loaded hydrophilic gel corticosteroid, fluticasone propionate (FP) was investigated systemically with response surface model (RSM) for promising dermal delivery the drug. Objectives: To achieve better penetration drug and to overcome generally associated adverse reactions corticosteroids, present study, explored formulation evaluation carriers (NLCs) FP in base. Methods: A central composite design proposed study effect processing materials on physicochemical properties NLC. High shear homogenization method stearic acid, isopropyl myristate poloxamer 407 used make different batches FP-NLCs. The optimized at significance level P<0.05. FTIR, DSC morphology studies were carried out product. product incorporated Carbopol P940 base evaluated its mechanical rheological properties, ex-vivo permeation skin irritation study. Results: It observed that using model, size (179 nm) stable (Zeta potential -26 mV) FP-NLC 85% entrapment efficiency achieved. nanogel exhibited spreadability 4.2 gm.cm/sec viscosity 92.6 cp. Approximately 3.5 times improvement no irritations animals reported application FP. Conclusion: Hence investigation created paradigm explore efficacy improved therapy dermatitis. Key words: Fluticasone propionate, Niosome, Central design, Gel, Ex-vivo permeation.